GC

Across TCGA cell cohorts, GC RNA expression is significantly associated with the go_rna of many other GO terms, with 871 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible GC-associated GO terms across cancer lineages are Cellular response to platelet-derived growth factor stimulus, Response to platelet-derived growth factor, and Indole-containing compound biosynthetic process. Each is linked with GC in more than 4 cancer types. Because this analysis shows association rather than direction, both GC-to-partner and partner-to-GC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to platelet-derived growth factor stimulus grouped by GC-low versus GC-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GC→partner) and Y-score (partner→GC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Cellular response to platelet-derived growth factor stimulus →	-0.135	-3.606	<.001	.005	3	5
LIVER	Response to platelet-derived growth factor →	-0.126	-3.510	.001	.005	3	4
LIVER	Indole-containing compound biosynthetic process →	+1.963	+3.887	<.001	<.001	3	3
LIVER	D-xylulose 5-phosphate metabolic process →	+0.190	+4.030	<.001	<.001	3	3
LIVER	Regulation of cholesterol import →	-0.172	-3.157	.003	.003	2	4
LIVER	Negative regulation of cholesterol import →	+1.688	+3.712	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 871 associations by consensus.

Cellular response to platelet-derived growth factor stimulus by GC expression — LIVER

Explore this box plot interactively →