GC

Across TCGA cell cohorts, GC mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GC-associated genes across cancer lineages are CD1B, PPBP, and FAM187B. Each is linked with GC in more than 1 cancer types. Because this analysis shows association rather than direction, both GC-to-partner and partner-to-GC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD1B grouped by GC-low versus GC-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GC→partner) and Y-score (partner→GC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CD1B →	+0.287	+3.523	<.001	.008	3	1
LUNG_SCLC	PPBP →	+0.447	+3.736	.001	.007	3	1
LUNG_SCLC	FAM187B →	+0.017	+3.817	.005	.004	3	1
LUNG_SCLC	OR10K2 →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	RESP18 →	+0.187	+3.898	<.001	.005	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

CD1B by GC expression — LUNG_SCLC

Explore this box plot interactively →