GBX1

Across TCGA cell cohorts, GBX1 mutation is significantly associated with the RNA expression of many other genes, with 280 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GBX1-associated genes across cancer lineages are PRAMEF1, ASB10, and MBL2. Each is linked with GBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBX1-to-partner and partner-to-GBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF1 grouped by GBX1-low versus GBX1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBX1→partner) and Y-score (partner→GBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRAMEF1 →	+0.010	+4.984	<.001	.002	3	1
BLOOD_Leukemia	ASB10 →	+0.074	+4.966	<.001	<.001	3	1
BLOOD_Leukemia	MBL2 →	+0.005	+4.269	<.001	.002	3	1
BLOOD_Leukemia	GP2 →	+0.055	+3.551	<.001	.009	3	1
BLOOD_Leukemia	OR6C75 →	+0.010	+4.984	<.001	.002	3	1
LARGE_INTESTINE	CDH20 →	+0.100	+2.807	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 280 associations by consensus.

PRAMEF1 by GBX1 expression — BLOOD_Leukemia

Explore this box plot interactively →