GBX1

Across TCGA pan-cancer cohorts, GBX1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of GBX1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GBX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GBX1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KICH, UCEC, and BLCA are the cancer types where GBX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GBX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	+0.026	.008	3	view →
UCEC	All	IV	+0.385	.013	2	view →
BLCA	All	All	+0.293	.039	2	view →
LUSC	Male	III,IV	−0.082	.003	2	view →
KIRC	Male	III,IV	+0.014	.023	2	view →
LIHC	All	II,III,IV	+0.012	.021	2	view →
LUAD	All	All	+0.167	.034	1	view →
STAD	Male	II,III,IV	+0.036	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

GBX1–KICH

Open the KICH breakdown →