GBP4

Across TCGA cell cohorts, GBP4 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GBP4-associated genes across cancer lineages are GNGT1, ASZ1, and CALHM4. Each is linked with GBP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBP4-to-partner and partner-to-GBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNGT1 grouped by GBP4-low versus GBP4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBP4→partner) and Y-score (partner→GBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GNGT1 →	+0.050	+4.551	.002	.004	3	1
BLOOD_Leukemia	ASZ1 →	+0.127	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CALHM4 →	+0.038	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	OR10T2 →	+1.072	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+2.014	+4.551	<.001	.004	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.092	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GNGT1 by GBP4 expression — BLOOD_Leukemia

Explore this box plot interactively →