GBP4

Across TCGA pan-cancer cohorts, GBP4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GBP4 data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher GBP4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GBP4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRP, and KIRC are the cancer types where GBP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.438	0.246	<.001	152	view →
KIRP	DFS	Tertile	II,III,IV	0.325	0.743	<.001	110	view →
KIRC	OS	Tertile	All	0.716	0.521	<.001	79	view →
UVM	DFS	Median	II,III,IV	0.424	0.714	.001	67	view →
BRCA	DFS	Quartile	All	0.969	0.918	.002	63	view →
OV	OS	Tertile	All	0.425	0.266	<.001	60	view →
HNSC	DFS	Median	All	0.697	0.545	<.001	45	view →
CESC	DFS	Quartile	All	0.887	0.717	.003	44	view →
LGG	OS	Median	All	0.746	0.872	<.001	40	view →
THCA	DFS	Median	IV	1.000	0.536	.003	30	view →
BLCA	OS	Tertile	III,IV	0.459	0.268	.021	25	view →
COAD	DFS	Quartile	All	0.836	0.572	.002	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GBP4–SKCM (OS)

Open the SKCM breakdown →