GBA3

Across TCGA patient cohorts, GBA3 protein abundance is significantly associated with the RNA expression of many other genes, with 4,572 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible GBA3-associated genes across cancer lineages are GRK3, AP3B2, and CD4. Each is linked with GBA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GBA3-to-partner and partner-to-GBA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GBA3 versus GRK3 in PDAC, with a Pearson correlation of -0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GBA3→partner) and Y-score (partner→GBA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	GRK3 →	-0.588	-0.641	<.001	.006	3	2
PDAC	AP3B2 →	-0.583	-0.779	<.001	.002	3	2
PDAC	CD4 →	-0.550	-0.666	.004	.001	3	2
CCRCC	PF4V1 →	+1.104	+0.730	.003	.006	3	2
PDAC	MAN1C1 →	-0.857	-0.777	<.001	<.001	3	2
PDAC	UNC13A →	-0.705	-0.647	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,572 associations by consensus.

GBA3 vs GRK3 — PDAC

Explore this scatter interactively →