GBA3

Across TCGA pan-cancer cohorts, GBA3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GBA3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GBA3 RNA is repressed in tumor relative to normal tissue. In most cancer types GBA3 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and LUAD are the cancer types where GBA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GBA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	III,IV	−5.824	<.001	11	view →
COAD	Female	II,III,IV	−3.824	<.001	11	view →
LUAD	Female	II,III,IV	−0.859	<.001	11	view →
LIHC	Male	III,IV	−3.286	<.001	9	view →
THCA	Male	II,III,IV	−0.823	<.001	8	view →
LUSC	All	All	−0.465	<.001	8	view →
KIRP	All	III,IV	−2.757	<.001	7	view →
UCEC	All	All	−1.016	.003	6	view →
CHOL	Female	All	−6.193	<.001	5	view →
READ	All	All	−2.415	<.001	5	view →
BRCA	All	III,IV	−0.146	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GBA3–KICH

Open the KICH breakdown →