GATA1

Across TCGA patient cohorts, GATA1 mutation is significantly associated with the RNA expression of many other genes, with 1,896 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATA1-associated genes across cancer lineages are LINC02510, SRP54, and ERI1. Each is linked with GATA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA1-to-partner and partner-to-GATA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02510 grouped by GATA1-low versus GATA1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA1→partner) and Y-score (partner→GATA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC02510 →	+0.038	+6.040	<.001	.001	3	2
UCEC	SRP54 →	+0.460	+2.265	.003	.005	3	2
UCEC	ERI1 →	+0.503	+1.971	.003	.008	3	2
UCEC	RBM28 →	+0.296	+2.102	.008	.001	3	2
UCEC	DRG2 →	+0.345	+3.638	.002	.001	3	2
UCEC	GID4 →	+0.418	+3.776	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,896 associations by consensus.

LINC02510 by GATA1 expression — BLCA

Explore this box plot interactively →