GATA1

Across TCGA pan-cancer cohorts, GATA1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated GATA1 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GATA1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GATA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, UCEC, and BLCA are the cancer types where GATA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.440	0.278	<.001	107	view →
UCEC	DFS	Median	III,IV	0.331	0.733	<.001	70	view →
BLCA	OS	Tertile	IV	0.235	0.648	.007	41	view →
COAD	OS	Tertile	All	0.918	0.798	.002	41	view →
ACC	DFS	Median	III,IV	0.579	0.115	.005	35	view →
LUAD	OS	Tertile	All	0.491	0.352	.002	33	view →
KIRP	OS	Tertile	II,III,IV	0.423	0.912	.012	32	view →
KIRC	DFS	Quartile	IV	0.429	0.785	.002	31	view →
DLBC	OS	Tertile	II,III,IV	1.000	0.390	.012	27	view →
SARC	OS	Tertile	All	0.657	0.366	<.001	24	view →
UCS	OS	Tertile	IV	0.224	0.883	.024	24	view →
BRCA	OS	Median	III,IV	0.957	0.847	.002	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GATA1–HNSC (OS)

Open the HNSC breakdown →