GATA1

Across TCGA pan-cancer cohorts, GATA1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GATA1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where GATA1 RNA is repressed in tumor relative to normal tissue. In most cancer types GATA1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and BLCA are the cancer types where GATA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GATA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.913	<.001	11	view →
LUSC	All	III,IV	−0.991	<.001	8	view →
BLCA	Male	IV	−0.805	<.001	8	view →
UCEC	All	All	−0.395	<.001	6	view →
KIRC	Male	All	+0.178	<.001	4	view →
KICH	All	All	−0.112	.007	4	view →
PRAD	All	All	−0.080	.048	2	view →
THCA	Female	II,III,IV	−0.107	.044	1	view →
LIHC	Male	All	−0.048	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GATA1–LUAD

Open the LUAD breakdown →