GATA1

Across TCGA patient cohorts, GATA1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GATA1-associated genes across cancer lineages are JNK2, MEK1, and MSH2. Each is linked with GATA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GATA1-to-partner and partner-to-GATA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by GATA1-low versus GATA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA1→partner) and Y-score (partner→GATA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.163	+2.348	.032	.018	3	1
UCEC	MEK1 →	+0.429	+2.087	.002	.005	2	2
UCEC	MSH2 →	-0.265	-1.848	.002	.049	3	1
UCEC	PI3K-p110-a →	-0.133	-1.700	.049	.042	3	1
UCEC	Tuberin_pT1462 →	+0.218	+1.710	.014	.025	3	1
UCEC	ATM →	-0.444	-2.446	.010	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK2 by GATA1 expression — UCEC

Explore this box plot interactively →