GATA1

Across TCGA cell cohorts, GATA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,793 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GATA1-associated GO terms across cancer lineages are Regulation of translational initiation, Regulation of myoblast fusion, and Negative regulation of myoblast fusion. Each is linked with GATA1 in more than 8 cancer types. Because this analysis shows association rather than direction, both GATA1-to-partner and partner-to-GATA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational initiation grouped by GATA1-low versus GATA1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GATA1→partner) and Y-score (partner→GATA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of translational initiation →	+0.090	+0.078	<.001	.004	3	9
CNS	Regulation of myoblast fusion →	+0.066	+0.033	<.001	<.001	3	9
STOMACH	Negative regulation of myoblast fusion →	+0.117	+0.060	.001	.006	3	9
STOMACH	Regulation of RNA splicing →	+0.064	+0.054	.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Protein stabilization →	+0.064	+0.050	<.001	<.001	3	9
SOFT_TISSUE	Regulation of mRNA processing →	+0.077	+0.045	<.001	.009	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,793 associations by consensus.

Regulation of translational initiation by GATA1 expression — STOMACH

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