GAPT

Across TCGA patient cohorts, GAPT mutation is significantly associated with the RNA expression of many other genes, with 3,098 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAPT-associated genes across cancer lineages are RNU6-675P, RPL32P36, and ALDOA. Each is linked with GAPT in more than 1 cancer types. Because this analysis shows association rather than direction, both GAPT-to-partner and partner-to-GAPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-675P grouped by GAPT-low versus GAPT-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAPT→partner) and Y-score (partner→GAPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-675P →	+0.352	+7.640	<.001	.009	3	2
LIHC	RPL32P36 →	+0.110	+4.274	<.001	.008	3	2
UCEC	ALDOA →	+0.504	+3.906	<.001	<.001	3	2
UCEC	SF3B5 →	+0.366	+2.855	.005	.001	3	2
UCEC	RPL35P9 →	+0.303	+1.915	<.001	.002	3	2
UCEC	DBNDD1 →	+0.596	+2.459	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,098 associations by consensus.

RNU6-675P by GAPT expression — BLCA

Explore this box plot interactively →