GAPT

Across TCGA pan-cancer cohorts, GAPT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GAPT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GAPT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GAPT is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

KIRC, KIRP, and LUAD are the cancer types where GAPT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAPT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+2.024	<.001	12	view →
KIRP	Male	All	+1.217	<.001	9	view →
LUAD	Male	II,III,IV	−0.916	<.001	9	view →
COAD	Female	II,III,IV	−0.757	<.001	9	view →
LUSC	Female	All	−1.635	<.001	8	view →
BLCA	All	All	−0.577	.006	8	view →
BRCA	All	III,IV	+0.847	<.001	6	view →
HNSC	Male	II,III,IV	−0.355	.009	5	view →
UCEC	All	All	−0.763	<.001	4	view →
PAAD	All	All	−2.364	.038	2	view →
THCA	Male	IV	+0.926	.004	2	view →
CHOL	All	All	+0.640	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GAPT–KIRC

Open the KIRC breakdown →