GALM

Across TCGA patient cohorts, GALM mutation is significantly associated with the RNA expression of many other genes, with 1,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GALM-associated genes across cancer lineages are IGHD2-15, RNU6-165P, and GPR75-ASB3. Each is linked with GALM in more than 1 cancer types. Because this analysis shows association rather than direction, both GALM-to-partner and partner-to-GALM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD2-15 grouped by GALM-low versus GALM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALM→partner) and Y-score (partner→GALM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD2-15 →	+1.763	+2.272	<.001	.001	3	2
UCEC	RNU6-165P →	+0.199	+3.008	.001	.007	3	2
UCEC	GPR75-ASB3 →	+0.104	+2.668	<.001	.002	3	1
UCEC	NBPF26 →	+0.383	+3.337	.001	.005	3	1
UCEC	RNA5SP536 →	+0.147	+3.606	<.001	.002	3	1
UCEC	RPS29P32 →	+0.657	+2.862	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,130 associations by consensus.

IGHD2-15 by GALM expression — UCEC

Explore this box plot interactively →