GALM

Across TCGA pan-cancer cohorts, GALM RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GALM’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GALM RNA is repressed in tumor relative to normal tissue. In most cancer types GALM is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRP, and KICH are the cancer types where GALM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GALM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.138	<.001	12	view →
KIRP	All	III,IV	−1.096	<.001	11	view →
KICH	Female	II,III,IV	−2.047	<.001	10	view →
STAD	All	II,III,IV	+1.251	<.001	9	view →
THCA	All	All	−0.293	<.001	9	view →
KIRC	Male	All	−0.706	<.001	8	view →
LUSC	Female	All	−0.921	<.001	6	view →
BLCA	Female	III,IV	+1.081	.023	4	view →
LUAD	All	III,IV	+0.489	.020	4	view →
READ	All	All	−1.007	.010	2	view →
CHOL	All	All	−0.708	.004	2	view →
PRAD	All	All	−0.662	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GALM–COAD

Open the COAD breakdown →