GALC

Across TCGA patient cohorts, GALC mutation is significantly associated with the RNA expression of many other genes, with 4,979 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GALC-associated genes across cancer lineages are COPS8P1, FEM1B, and FBXO36-IT1. Each is linked with GALC in more than 2 cancer types. Because this analysis shows association rather than direction, both GALC-to-partner and partner-to-GALC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS8P1 grouped by GALC-low versus GALC-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALC→partner) and Y-score (partner→GALC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	COPS8P1 →	+0.107	+3.719	<.001	.008	3	3
UCEC	FEM1B →	+0.367	+1.864	.003	.004	3	3
HNSC	FBXO36-IT1 →	+0.111	+4.452	<.001	.006	3	2
HNSC	RNU7-60P →	+0.421	+5.468	<.001	.002	3	2
HNSC	MIR4714 →	+0.674	+4.624	<.001	.004	3	2
UCEC	COX15 →	+0.454	+2.115	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,979 associations by consensus.

COPS8P1 by GALC expression — BLCA

Explore this box plot interactively →