GALC

Across TCGA pan-cancer cohorts, GALC RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GALC’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GALC RNA is repressed in tumor relative to normal tissue. In most cancer types GALC is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and LUAD are the cancer types where GALC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GALC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.357	<.001	11	view →
LUSC	All	II,III,IV	−1.093	<.001	9	view →
LUAD	Male	II,III,IV	−0.958	<.001	9	view →
KICH	Female	II,III,IV	−1.665	<.001	8	view →
COAD	Female	All	−0.948	<.001	6	view →
STAD	Female	All	+1.191	.012	5	view →
CHOL	Male	All	+1.505	.006	2	view →
UCEC	All	All	−0.828	.004	2	view →
KIRP	All	All	−0.544	.002	2	view →
LIHC	Male	III,IV	−0.776	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GALC–THCA

Open the THCA breakdown →