GADD45G

Across TCGA cell cohorts, GADD45G RNA expression is significantly associated with the go_rna of many other GO terms, with 4,333 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GADD45G-associated GO terms across cancer lineages are Positive regulation of brown fat cell differentiation, Vesicle localization, and Response to topologically incorrect protein. Each is linked with GADD45G in more than 7 cancer types. Because this analysis shows association rather than direction, both GADD45G-to-partner and partner-to-GADD45G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of brown fat cell differentiation grouped by GADD45G-low versus GADD45G-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GADD45G→partner) and Y-score (partner→GADD45G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of brown fat cell differentiation →	+0.091	+0.950	.008	.006	3	8
BREAST	Vesicle localization →	+0.057	+2.094	<.001	<.001	3	8
OVARY	Response to topologically incorrect protein →	+0.089	+1.049	<.001	<.001	3	8
BREAST	Adenylate cyclase-activating serotonin receptor signaling pathway →	+0.166	+1.726	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	ATP biosynthetic process →	+0.101	+0.751	<.001	.002	3	8
OVARY	Purine ribonucleoside triphosphate metabolic process →	+0.070	+0.797	<.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,333 associations by consensus.

Positive regulation of brown fat cell differentiation by GADD45G expression — LARGE_INTESTINE

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