GADD45B

Across TCGA patient cohorts, GADD45B mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GADD45B-associated genes across cancer lineages are KRTAP21-1, RNA5SP136, and MTCO1P35. Each is linked with GADD45B in more than 1 cancer types. Because this analysis shows association rather than direction, both GADD45B-to-partner and partner-to-GADD45B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP21-1 grouped by GADD45B-low versus GADD45B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GADD45B→partner) and Y-score (partner→GADD45B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KRTAP21-1 →	+0.215	+5.242	<.001	.007	3	2
UCEC	RNA5SP136 →	+0.692	+5.299	<.001	.006	3	2
UCEC	MTCO1P35 →	+0.532	+5.621	.001	.004	3	2
SKCM	LINC02424 →	+0.142	+5.097	<.001	.008	3	2
SKCM	OR1L1 →	+0.043	+5.594	<.001	.004	3	1
SKCM	HNRNPCL4 →	+0.180	+5.097	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

KRTAP21-1 by GADD45B expression — UCEC

Explore this box plot interactively →