GADD45B

Across TCGA pan-cancer cohorts, GADD45B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GADD45B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where GADD45B RNA is repressed in tumor relative to normal tissue. In most cancer types GADD45B is over-expressed in tumor, although a few such as LUSC and LIHC show the opposite, repressed pattern.

LUSC, LIHC, and LUAD are the cancer types where GADD45B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GADD45B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−2.914	<.001	8	view →
LIHC	Female	All	−1.388	<.001	8	view →
LUAD	Male	All	−1.347	<.001	8	view →
KIRP	All	II,III,IV	−1.913	<.001	7	view →
KICH	Female	All	−1.597	<.001	7	view →
HNSC	All	All	−0.810	<.001	7	view →
BLCA	Male	All	−2.075	<.001	6	view →
UCEC	All	All	−1.395	<.001	6	view →
CHOL	Male	All	−1.599	<.001	4	view →
THCA	Female	All	−1.156	<.001	4	view →
STAD	All	All	−1.060	.007	4	view →
KIRC	All	II,III,IV	−0.563	.018	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GADD45B–LUSC

Open the LUSC breakdown →