GADD45B

Across TCGA pan-cancer cohorts, GADD45B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated GADD45B data layer compared with 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GADD45B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GADD45B expression acts as an unfavorable survival marker, although some lineages such as SKCM and LIHC show a favorable association.

LUSC, SKCM, and COAD are the cancer types where GADD45B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.304	0.477	.002	66	view →
SKCM	OS	Median	II,III,IV	0.425	0.203	<.001	58	view →
COAD	DFS	Quartile	All	0.450	0.799	<.001	40	view →
ESCA	OS	Quartile	II,III,IV	0.423	0.759	<.001	36	view →
OV	DFS	Quartile	All	0.456	0.577	.016	36	view →
STAD	OS	Median	II,III,IV	0.496	0.638	.008	29	view →
LGG	OS	Quartile	All	0.841	0.950	<.001	29	view →
CHOL	OS	Median	All	0.523	0.946	.003	28	view →
LIHC	OS	Tertile	All	0.822	0.689	.001	28	view →
UVM	DFS	Quartile	II,III,IV	0.366	0.905	.002	22	view →
SCLC	DFS	Quartile	III,IV	0.550	0.206	.003	20	view →
ACC	OS	Median	III,IV	0.609	0.845	.013	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GADD45B–LUSC (DFS)

Open the LUSC breakdown →