GADD45B

Across TCGA cell cohorts, GADD45B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,880 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GADD45B-associated GO terms across cancer lineages are Regulation of protein K48-linked ubiquitination, Dentinogenesis, and Metanephric glomerular mesangium development. Each is linked with GADD45B in more than 12 cancer types. Because this analysis shows association rather than direction, both GADD45B-to-partner and partner-to-GADD45B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein K48-linked ubiquitination grouped by GADD45B-low versus GADD45B-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GADD45B→partner) and Y-score (partner→GADD45B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of protein K48-linked ubiquitination →	+0.209	+1.473	<.001	.002	3	13
BONE	Dentinogenesis →	+2.137	+2.393	<.001	<.001	3	12
STOMACH	Metanephric glomerular mesangium development →	+0.992	+1.919	.001	.001	3	12
STOMACH	Negative regulation of canonical NF-kappaB signal transduction →	+0.057	+2.351	.008	.003	3	12
LUNG_NSCLC_LUSC	Protein activation cascade →	+0.453	+2.258	<.001	<.001	3	11
CNS	Cellular response to environmental stimulus →	+0.048	+1.724	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,880 associations by consensus.

Regulation of protein K48-linked ubiquitination by GADD45B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →