GAD2

Across TCGA patient cohorts, GAD2 mutation is significantly associated with the RNA expression of many other genes, with 6,315 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAD2-associated genes across cancer lineages are FANCA, BNIP3P6, and WDR62. Each is linked with GAD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GAD2-to-partner and partner-to-GAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCA grouped by GAD2-low versus GAD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAD2→partner) and Y-score (partner→GAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCA →	+0.761	+3.087	<.001	<.001	3	4
READ	BNIP3P6 →	+0.352	+4.925	<.001	.004	3	3
LUAD	WDR62 →	+0.862	+3.205	<.001	.009	3	3
UCEC	PPIL2 →	+0.292	+1.698	.001	<.001	3	3
LUAD	CRYBB2P1 →	+0.493	+3.528	<.001	.002	3	3
UCEC	POLE2 →	+0.483	+1.928	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,315 associations by consensus.

FANCA by GAD2 expression — UCEC

Explore this box plot interactively →