GAD2

Across TCGA pan-cancer cohorts, GAD2 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated GAD2 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GAD2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GAD2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LGG show a favorable association.

UCEC, DLBC, and LIHC are the cancer types where GAD2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.788	0.463	.006	74	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.017	40	view →
LIHC	OS	Tertile	II,III,IV	0.477	0.727	.001	39	view →
STAD	DFS	Quartile	II,III,IV	0.529	0.714	.003	31	view →
UCS	OS	Quartile	II,III,IV	0.423	0.849	.004	22	view →
MESO	DFS	Quartile	All	0.198	0.418	.006	18	view →
COAD	OS	Tertile	IV	0.064	0.678	<.001	18	view →
KIRP	DFS	Median	III,IV	0.475	0.829	.004	15	view →
LGG	DFS	Quartile	All	0.536	0.341	.006	12	view →
CHOL	OS	Tertile	All	1.000	0.215	.006	12	view →
SARC	DFS	Median	All	0.547	0.707	.005	11	view →
PAAD	DFS	Quartile	All	0.562	0.230	.002	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GAD2–UCEC (OS)

Open the UCEC breakdown →