GABRA6

Across TCGA patient cohorts, GABRA6 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRA6-associated genes across cancer lineages are PKC-a_pS657, INPP4B, and PKC-a. Each is linked with GABRA6 in more than 4 cancer types. Because this analysis shows association rather than direction, both GABRA6-to-partner and partner-to-GABRA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a_pS657 grouped by GABRA6-low versus GABRA6-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA6→partner) and Y-score (partner→GABRA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PKC-a_pS657 →	-0.397	-3.000	.042	.036	3	4
LUAD	INPP4B →	-0.444	-1.983	.005	.009	3	4
LUAD	PKC-a →	-0.203	-2.459	.034	.018	3	4
COAD	eIF4E →	+0.234	+3.012	.007	.018	3	4
COAD	Caspase-7-cleavedD198 →	+1.015	+3.178	.009	.010	3	4
STAD	FASN →	+0.617	+2.823	.004	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

PKC-a_pS657 by GABRA6 expression — STAD

Explore this box plot interactively →