GABRA6

Across TCGA pan-cancer cohorts, GABRA6 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GABRA6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GABRA6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GABRA6 is over-expressed in tumor, although a few such as KIRC and UCEC show the opposite, repressed pattern.

THCA, KIRC, and UCEC are the cancer types where GABRA6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GABRA6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	+0.247	<.001	11	view →
KIRC	All	All	−0.005	<.001	9	view →
UCEC	All	All	−0.023	.031	2	view →
LUSC	All	II,III,IV	+0.007	.027	2	view →
COAD	Female	IV	−0.025	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GABRA6–THCA

Open the THCA breakdown →