GABRA6

Across TCGA pan-cancer cohorts, GABRA6 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated GABRA6 data layer compared with 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GABRA6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GABRA6 expression acts as an unfavorable survival marker, although some lineages such as UCS and MESO show a favorable association.

COAD, READ, and UCS are the cancer types where GABRA6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	II,III,IV	0.207	0.580	.001	96	view →
READ	DFS	Tertile	III,IV	0.149	0.765	<.001	72	view →
UCS	OS	Quartile	III,IV	0.704	0.214	.007	68	view →
MESO	OS	Tertile	II,III,IV	0.515	0.234	.005	60	view →
KIRC	DFS	Tertile	III,IV	0.195	0.534	.001	54	view →
DLBC	OS	Quartile	III,IV	0.129	0.797	<.001	53	view →
OV	OS	Tertile	IV	0.557	0.786	.003	36	view →
BLCA	DFS	Tertile	All	0.456	0.643	.010	18	view →
SCLC	OS	Tertile	II,III,IV	0.277	0.532	.033	18	view →
PAAD	OS	Tertile	II,III,IV	0.890	0.383	.020	18	view →
THYM	OS	Tertile	All	0.732	0.958	.029	15	view →
LGG	DFS	Median	All	0.804	0.663	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

GABRA6–COAD (OS)

Open the COAD breakdown →