GABRA6

Across TCGA cell cohorts, GABRA6 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GABRA6-associated genes across cancer lineages are GFRA4, TBX5, and SLC7A1. Each is linked with GABRA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRA6-to-partner and partner-to-GABRA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by GABRA6-low versus GABRA6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA6→partner) and Y-score (partner→GABRA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GFRA4 →	+0.012	+3.440	<.001	.001	3	2
BREAST	TBX5 →	+0.484	+3.906	<.001	.002	3	2
LUNG_NSCLC_LUAD	SLC7A1 →	+0.563	+3.206	.004	.006	3	1
LUNG_NSCLC_LUAD	KCNA6 →	+0.014	+2.928	<.001	<.001	3	1
LUNG_NSCLC_LUAD	EDDM3B →	+0.049	+2.564	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR5B21 →	+0.025	+2.786	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

GFRA4 by GABRA6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →