GABRA4

Across TCGA cell cohorts, GABRA4 mutation is significantly associated with the drug of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GABRA4-associated genes across cancer lineages are AZD8055, Avagacestat, and YK-4-279. Each is linked with GABRA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRA4-to-partner and partner-to-GABRA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD8055 grouped by GABRA4-low versus GABRA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA4→partner) and Y-score (partner→GABRA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD8055 →	+0.522	+3.000	.023	.021	3	1
LARGE_INTESTINE	Avagacestat →	+0.384	+2.807	.012	.046	3	1
LARGE_INTESTINE	YK-4-279 →	+0.677	+2.871	.040	.021	3	1
LARGE_INTESTINE	Afuresertib →	+0.575	+2.871	.031	.021	3	1
LARGE_INTESTINE	AZD5363 →	+0.555	+2.871	.035	.021	3	1
LARGE_INTESTINE	Ipatasertib →	+0.599	+2.871	.019	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

AZD8055 by GABRA4 expression — LARGE_INTESTINE

Explore this box plot interactively →