GABRA4

Across TCGA pan-cancer cohorts, GABRA4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of GABRA4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where GABRA4 RNA is repressed in tumor relative to normal tissue. In most cancer types GABRA4 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and KICH are the cancer types where GABRA4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GABRA4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−0.202	<.001	11	view →
KIRC	Male	All	−0.159	<.001	10	view →
KICH	All	II,III,IV	−0.137	<.001	8	view →
BRCA	Female	II,III,IV	−0.133	<.001	6	view →
HNSC	Male	III,IV	−0.101	.004	5	view →
LUAD	Female	III,IV	−0.061	<.001	5	view →
THCA	Female	All	−0.011	<.001	5	view →
ESCA	Female	All	−0.070	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

GABRA4–KIRP

Open the KIRP breakdown →