GABRA4

Across TCGA pan-cancer cohorts, GABRA4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated GABRA4 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher GABRA4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GABRA4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

KICH, UVM, and KIRC are the cancer types where GABRA4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.597	0.942	<.001	106	view →
UVM	DFS	Tertile	All	0.423	0.822	<.001	77	view →
KIRC	DFS	Tertile	II,III,IV	0.688	0.433	.002	54	view →
COAD	DFS	Median	All	0.761	0.605	<.001	38	view →
LUSC	DFS	Tertile	III,IV	0.402	0.693	.002	36	view →
CHOL	DFS	Median	III,IV	0.031	0.505	.003	33	view →
CESC	OS	Tertile	III,IV	0.106	0.459	.042	30	view →
OV	OS	Tertile	IV	0.394	0.655	.015	30	view →
ESCA	DFS	Tertile	III,IV	0.473	0.218	.003	28	view →
LUAD	DFS	Median	IV	0.653	0.978	.011	18	view →
UCEC	OS	Tertile	IV	0.199	0.534	.017	18	view →
LGG	DFS	Quartile	All	0.900	0.787	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GABRA4–KICH (DFS)

Open the KICH breakdown →