GABRA3

Across TCGA cell cohorts, GABRA3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GABRA3-associated genes across cancer lineages are PFN3, MYF5, and ACSM2B. Each is linked with GABRA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRA3-to-partner and partner-to-GABRA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN3 grouped by GABRA3-low versus GABRA3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA3→partner) and Y-score (partner→GABRA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PFN3 →	+0.081	+4.450	<.001	.004	3	2
CNS	MYF5 →	+0.756	+5.321	<.001	.005	3	1
CNS	ACSM2B →	+0.013	+5.321	<.001	.005	3	1
OVARY	SPACA1 →	+0.017	+4.807	<.001	.003	3	1
SKIN	KRTAP5-2 →	+0.321	+3.731	<.001	.002	3	1
SKIN	TBC1D3 →	+0.481	+2.882	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PFN3 by GABRA3 expression — OVARY

Explore this box plot interactively →