GABRA3

Across TCGA pan-cancer cohorts, GABRA3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GABRA3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GABRA3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GABRA3 is over-expressed in tumor, although a few such as PRAD and KICH show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where GABRA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GABRA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.126	<.001	11	view →
LUAD	All	All	+0.559	<.001	8	view →
LUSC	Male	All	+2.454	<.001	7	view →
BLCA	Female	III,IV	+1.811	.013	6	view →
BRCA	Female	II,III,IV	+0.461	<.001	4	view →
LIHC	All	All	+0.426	<.001	4	view →
PRAD	All	All	−0.248	.002	2	view →
KICH	Female	II,III,IV	−0.045	.026	2	view →
STAD	Female	III,IV	−0.130	.044	1	view →
COAD	Male	II,III,IV	−0.117	.028	1	view →
THCA	All	IV	+0.012	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GABRA3–HNSC

Open the HNSC breakdown →