GABRA1

Across TCGA patient cohorts, GABRA1 mutation is significantly associated with the RNA expression of many other genes, with 4,900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRA1-associated genes across cancer lineages are RCC1, NDUFA12, and MTFP1. Each is linked with GABRA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GABRA1-to-partner and partner-to-GABRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCC1 grouped by GABRA1-low versus GABRA1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA1→partner) and Y-score (partner→GABRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RCC1 →	+0.781	+3.371	.002	.004	3	5
STAD	NDUFA12 →	+0.507	+3.371	<.001	.004	3	4
COAD	MTFP1 →	+0.589	+3.183	.002	.009	3	4
UCEC	TIPIN →	+0.484	+2.021	<.001	<.001	3	4
UCEC	UBE2T →	+0.638	+2.042	<.001	<.001	3	4
UCEC	FANCE →	+0.461	+2.828	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,900 associations by consensus.

RCC1 by GABRA1 expression — STAD

Explore this box plot interactively →