GABRA1

Across TCGA pan-cancer cohorts, GABRA1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of GABRA1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GABRA1 RNA is repressed in tumor relative to normal tissue. In most cancer types GABRA1 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, THCA, and STAD are the cancer types where GABRA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GABRA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.021	<.001	6	view →
THCA	All	All	+0.076	<.001	4	view →
STAD	Male	All	−0.054	.008	4	view →
LUAD	Female	All	−0.022	.001	4	view →
BRCA	All	II,III,IV	+0.011	.007	4	view →
ESCA	All	All	−0.182	.030	1	view →
LUSC	Female	II,III,IV	−0.012	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

GABRA1–COAD

Open the COAD breakdown →