GAB2

Across TCGA cell cohorts, GAB2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible GAB2-associated genes across cancer lineages are KRTAP9-1, CNTNAP3C, and CPLX4. Each is linked with GAB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAB2-to-partner and partner-to-GAB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-1 grouped by GAB2-low versus GAB2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB2→partner) and Y-score (partner→GAB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP9-1 →	+0.053	+6.247	<.001	<.001	3	1
BLOOD_Leukemia	CNTNAP3C →	+0.085	+3.729	.005	.009	3	1
LARGE_INTESTINE	CPLX4 →	+0.025	+3.766	.001	.004	3	1
OVARY	FCRL4 →	+0.004	+3.405	<.001	.005	3	1
OVARY	OR9Q1 →	+0.003	+3.807	<.001	.009	3	1
OVARY	KHDC3L →	+0.060	+3.974	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

KRTAP9-1 by GAB2 expression — BLOOD_Lymphoma

Explore this box plot interactively →