G3BP1

Across TCGA patient cohorts, G3BP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,905 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible G3BP1-associated proteins across cancer lineages are NPM1, NPM1_S254, and GEMIN5. Each is linked with G3BP1 in more than 7 cancer types. Because this analysis shows association rather than direction, both G3BP1-to-partner and partner-to-G3BP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, G3BP1 versus NPM1 in LSCC, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (G3BP1→partner) and Y-score (partner→G3BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NPM1 →	+0.413	+0.538	<.001	<.001	3	7
LUAD	NPM1_S254 →	+1.081	+0.351	<.001	<.001	3	7
HNSC	GEMIN5 →	+0.254	+0.608	<.001	<.001	2	8
LUAD	NOP16 →	+0.510	+0.353	<.001	<.001	3	6
GBM	KDM3B →	+0.314	+0.314	<.001	<.001	3	6
PDAC	UTP4 →	+0.318	+0.315	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,905 associations by consensus.

G3BP1 vs NPM1 — LSCC

Explore this scatter interactively →