G3BP1

Across TCGA pan-cancer cohorts, G3BP1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of G3BP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where G3BP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types G3BP1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, STAD, and LIHC are the cancer types where G3BP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in G3BP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.811	<.001	11	view →
STAD	Male	II,III,IV	+0.972	<.001	9	view →
LIHC	Male	II,III,IV	+0.961	<.001	9	view →
COAD	Male	All	+0.764	<.001	9	view →
BLCA	Male	III,IV	+0.835	<.001	7	view →
LUAD	Male	All	+0.542	<.001	7	view →
BRCA	All	II,III,IV	+0.279	<.001	6	view →
CHOL	Male	All	+1.508	<.001	5	view →
KICH	All	All	−0.941	<.001	5	view →
LUSC	Male	II,III,IV	+0.583	<.001	5	view →
KIRC	All	All	+0.296	<.001	5	view →
READ	All	III,IV	+1.275	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

G3BP1–HNSC

Open the HNSC breakdown →