G3BP1

Across TCGA pan-cancer cohorts, G3BP1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated G3BP1 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher G3BP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated G3BP1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KIRP, KIRC, and PAAD are the cancer types where G3BP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.852	0.965	<.001	83	view →
KIRC	DFS	Tertile	All	0.772	0.478	<.001	60	view →
PAAD	OS	Quartile	All	0.405	0.770	<.001	51	view →
CESC	DFS	Median	III,IV	0.595	0.869	.006	50	view →
HNSC	OS	Median	All	0.283	0.518	.002	40	view →
ACC	DFS	Quartile	All	0.415	0.783	.006	34	view →
KICH	DFS	Quartile	II,III,IV	0.445	0.919	.012	33	view →
UVM	DFS	Median	III,IV	0.274	0.680	.009	32	view →
READ	DFS	Quartile	II,III,IV	0.858	0.398	.003	31	view →
SCLC	OS	Tertile	All	0.383	0.642	.018	27	view →
LGG	OS	Tertile	All	0.728	0.926	<.001	26	view →
LIHC	OS	Quartile	All	0.667	0.858	<.001	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

G3BP1–KIRP (DFS)

Open the KIRP breakdown →