G3BP1

Across TCGA patient cohorts, G3BP1 mutation is significantly associated with the RNA expression of many other genes, with 1,941 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible G3BP1-associated genes across cancer lineages are RNA5SP229, BTBD10, and DRD2. Each is linked with G3BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both G3BP1-to-partner and partner-to-G3BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP229 grouped by G3BP1-low versus G3BP1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G3BP1→partner) and Y-score (partner→G3BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP229 →	+0.433	+5.069	<.001	.008	3	2
UCEC	BTBD10 →	+0.384	+3.032	.002	<.001	3	2
UCEC	DRD2 →	-0.411	-3.968	.002	<.001	3	2
UCEC	MRPL49 →	+0.490	+3.087	<.001	<.001	3	2
UCEC	SLC25A4 →	+0.528	+1.847	<.001	<.001	3	2
COAD	ATP5F1A →	+0.728	+3.625	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,941 associations by consensus.

RNA5SP229 by G3BP1 expression — HNSC

Explore this box plot interactively →