G3BP1

Across TCGA cell cohorts, G3BP1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible G3BP1-associated genes across cancer lineages are SAMM50, PRDM7, and MEPE. Each is linked with G3BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both G3BP1-to-partner and partner-to-G3BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAMM50 grouped by G3BP1-low versus G3BP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G3BP1→partner) and Y-score (partner→G3BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SAMM50 →	+0.639	+3.064	<.001	.009	3	1
LARGE_INTESTINE	PRDM7 →	+0.200	+3.302	<.001	.006	3	1
LARGE_INTESTINE	MEPE →	+0.046	+2.560	.001	.008	3	1
LARGE_INTESTINE	GPR27 →	+1.008	+3.839	<.001	<.001	3	1
LARGE_INTESTINE	PYGO1 →	+0.789	+3.439	.005	.003	3	1
LARGE_INTESTINE	NANOS2 →	+0.040	+2.556	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

SAMM50 by G3BP1 expression — LARGE_INTESTINE

Explore this box plot interactively →