G3BP1

Across TCGA cell cohorts, G3BP1 mutation is significantly associated with the mutation status of many other genes, with 3,001 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible G3BP1-associated genes across cancer lineages are GIT1, CEP72, and FAM20B. Each is linked with G3BP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both G3BP1-to-partner and partner-to-G3BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIT1 grouped by G3BP1-low versus G3BP1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G3BP1→partner) and Y-score (partner→G3BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GIT1 →	+4.415	+4.977	.007	.007	1	3
OVARY	CEP72 →	+5.415	+5.415	.004	.004	1	3
OVARY	FAM20B →	+5.415	+5.415	.004	.004	1	3
OVARY	PKD2 →	+5.415	+5.415	.004	.004	1	3
OVARY	PROZ →	+4.415	+4.977	.007	.007	1	3
OVARY	UHRF1BP1 →	+5.415	+5.415	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,001 associations by consensus.

GIT1 by G3BP1 expression — OVARY

Explore this box plot interactively →