G2E3

Across TCGA patient cohorts, G2E3 protein abundance is significantly associated with the RNA expression of many other genes, with 10,829 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible G2E3-associated genes across cancer lineages are BVES, CCNB1IP1, and MAN2B1. Each is linked with G2E3 in more than 1 cancer types. Because this analysis shows association rather than direction, both G2E3-to-partner and partner-to-G2E3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, G2E3 versus BVES in GBM, with a Pearson correlation of 0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G2E3→partner) and Y-score (partner→G2E3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BVES →	+1.186	+0.279	.007	<.001	3	2
LSCC	CCNB1IP1 →	+0.864	+0.675	.003	.007	3	1
LSCC	MAN2B1 →	+0.505	+0.699	.002	<.001	3	1
LSCC	GOLT1B →	+1.262	+0.742	.002	.009	3	1
LSCC	TBX18 →	+2.177	+0.815	.007	.006	3	1
LSCC	PODXL2 →	+1.232	+0.880	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,829 associations by consensus.

G2E3 vs BVES — GBM

Explore this scatter interactively →