G2E3

Across TCGA pan-cancer cohorts, G2E3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of G2E3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where G2E3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types G2E3 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, BLCA, and THCA are the cancer types where G2E3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in G2E3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.285	<.001	12	view →
BLCA	Male	III,IV	+1.247	<.001	11	view →
THCA	Male	III,IV	−1.010	<.001	10	view →
LIHC	Male	All	+0.709	<.001	8	view →
LUSC	Male	II,III,IV	+0.981	<.001	7	view →
LUAD	Male	II,III,IV	+0.828	<.001	7	view →
STAD	All	All	+0.643	<.001	6	view →
BRCA	All	II,III,IV	+0.514	<.001	6	view →
KIRC	All	II,III,IV	−0.278	.003	6	view →
CHOL	Male	All	+1.411	<.001	5	view →
COAD	Male	All	+0.543	.001	4	view →
ESCA	All	All	+0.923	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

G2E3–HNSC

Open the HNSC breakdown →