FZD1

Across TCGA patient cohorts, FZD1 mutation is significantly associated with the RNA expression of many other genes, with 4,679 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD1-associated genes across cancer lineages are RN7SL248P, BNIP3L, and CENPU. Each is linked with FZD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FZD1-to-partner and partner-to-FZD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by FZD1-low versus FZD1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD1→partner) and Y-score (partner→FZD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RN7SL248P →	+0.118	+6.169	<.001	<.001	3	3
COAD	BNIP3L →	+0.540	+1.920	.009	.009	3	3
UCEC	CENPU →	+0.773	+2.032	<.001	<.001	3	3
COAD	CXXC1 →	+0.421	+3.713	.001	<.001	3	3
UCEC	SFXN1 →	+0.555	+4.413	<.001	<.001	3	3
COAD	SMAD2 →	+0.349	+1.933	.009	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,679 associations by consensus.

RN7SL248P by FZD1 expression — LIHC

Explore this box plot interactively →