FZD1

Across TCGA pan-cancer cohorts, FZD1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FZD1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where FZD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FZD1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where FZD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FZD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	+1.830	<.001	11	view →
KIRC	Male	All	+1.567	<.001	11	view →
HNSC	All	III,IV	+1.097	<.001	10	view →
KICH	Female	All	−2.330	<.001	9	view →
COAD	Female	II,III,IV	−0.517	<.001	7	view →
UCEC	All	All	−0.697	.008	4	view →
BRCA	Female	All	−0.316	.017	3	view →
CHOL	All	All	+2.507	<.001	2	view →
READ	Female	All	−1.291	.007	2	view →
PRAD	All	All	−0.381	.007	2	view →
STAD	Male	II,III,IV	+0.737	.032	1	view →
THCA	Male	All	−0.535	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FZD1–KIRP

Open the KIRP breakdown →