FYN

Across TCGA patient cohorts, FYN protein abundance is significantly associated with the RNA expression of many other genes, with 16,833 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FYN-associated genes across cancer lineages are PPP1R16B, CHST11, and CSF2RB. Each is linked with FYN in more than 5 cancer types. Because this analysis shows association rather than direction, both FYN-to-partner and partner-to-FYN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FYN versus PPP1R16B in GBM, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FYN→partner) and Y-score (partner→FYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP1R16B →	+1.603	+0.473	<.001	<.001	3	6
BRCA	CHST11 →	+1.111	+0.643	<.001	<.001	3	5
BRCA	CSF2RB →	+1.374	+0.768	<.001	<.001	3	5
HNSC	GZMB →	+1.216	+0.250	<.001	.006	3	5
GBM	RASSF2 →	+0.923	+0.528	<.001	<.001	3	5
BRCA	PIM2 →	+1.392	+0.776	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,833 associations by consensus.

FYN vs PPP1R16B — GBM

Explore this scatter interactively →