FYN

Across TCGA pan-cancer cohorts, FYN RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FYN’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FYN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FYN is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

THCA, KIRC, and HNSC are the cancer types where FYN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FYN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.638	<.001	11	view →
KIRC	Female	All	+1.252	<.001	11	view →
HNSC	Female	II,III,IV	+1.002	<.001	11	view →
BLCA	All	III,IV	−1.320	.002	9	view →
UCEC	All	III,IV	−1.642	<.001	8	view →
KICH	Male	II,III,IV	−1.398	<.001	8	view →
LUAD	All	All	−0.583	<.001	7	view →
BRCA	All	III,IV	−0.856	<.001	6	view →
LUSC	All	All	−0.859	<.001	5	view →
LIHC	All	All	−0.369	.003	3	view →
ESCA	Male	All	+1.274	.012	2	view →
KIRP	Male	All	−0.770	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FYN–THCA

Open the THCA breakdown →